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Abstract #0910

Age-Related Changes of Susceptibility and Phase Changes at Subependymal Nodes in Infants and Children with Tuberous Sclerosis.

Tetsu Niwa1, Noriko Aida2, Taro Takahara3, Tomohiro Yamashita1, Noriharu Yanagimachi1, Tomoaki Nagaoka4, Yutaka Imai1

1Radiology, Tokai University School of Medicine, Isehara, Kanagawa, Japan; 2Radiology, Kanagawa Children's Medical Center, Yokohama, Kanagawa, Japan; 3Biomedical Engineering, Tokai University School of Engineering, Isehara, Kanagawa, Japan; 4Electromagnetic Compatibility Laboratory, Applied Electromagnetic Research Institute, National Institute of Information and Communications Technology, Koganei, Tokyo, Japan

We assessed the age-related changes of SWI and phase image at the subependymal nodules in infants and children with tuberous sclerosis. There was no signal loss on SWI and no phase shift on phase image at the subependymal nodules in neonates, those changed by aging. The occurrence of the phase shift at the subependymal nodules was identified around 1-year-old, while signal loss on SWI appeared after 2-year-old. The manifestation of the phase shift at the subependymal nodules seems to precede that of signal loss on SWI.

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