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Abstract #0880

3D Carotid Wall T1 Quantification Using Variable Flip Angle 3D Merge with Steady-State Recovery

Bram F. Coolen1, Dennis F.R. Heijtel1, Wouter V. Potters1, Aart J. Nederveen1

1Department of Radiology, Academic Medical Center Amsterdam, Amsterdam, Netherlands

A novel method for 3D carotid artery T1 quantification is presented, based on combining 3D Merge black-blood imaging with a variable flip angle T1 analysis. The application of a dummy pulse train following read-out ensures steady-state conditions for the acquired data, which is needed for correct T1 estimation. Simulations, phantom and in vivo measurements were performed to assess the feasibility of the proposed method.

Keywords

acceleration accuracy accurate allowing although anatomical apart applications artery assess atherosclerosis behavior bifurcations black blood blurring bottom burden calcifications capable cardiovascular carotid circulation coil coils components composition conditions considering contrast core coronal created crucial curves dataset degree delineation determining diagnostic distinguished dotted dummy equation equations estimation estimations events example expected extensively favorable feasibility findings flexible foresee form future gold gradients healthy hemorrhage illustrates illustrating importantly improving in vivo incomplete inter intra justifying knowledge latter limited linearized lipid literature little locker longitudinal look magnetization magnified maintain many mapping measured mentioned merge minimize modulation module mostly motion neck occurred occurs overcome perfect phantom pixel plaque preparation proposed protocol pulse pulses qualitative quantification quantitative radiology read recovery registered reproducibility required restore risk saturation section segmented sensitivity serve short sides significantly simulated simulations slight somewhat sonar steady stroke studied studies suffer suppression terms theoretical tool transversal underestimation unfortunately variable variations various vessel views vulnerability wall weightings wise