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Abstract #0747

Risk Factors for Immediate Adverse Events to Gadolinium-Based Contrast Agents (GBCA)

Silvina P. Dutruel1, Zhitong Zou1, Martin R. Prince1

1Radiology, Weill Cornell Medical College, New York, NY, United States

After reviewing the FDA Adverse Event Reporting System database for immediate reactions due to Gadolinium-based contrast agents (GBCA) we analyzed more than 4500 cases excluding Nephrogenic Systemic Fibrosis (NSF) occurring in the United States from January 2004 to March 2012. The peak age incidence was between 20-60 years. Interestingly, males had nearly twice the death rate of females even though they had fewer reported reactions (p<0.0001). Immediate adverse events showed a marked increase in reporting after the association between NSF and GBCA. Urticaria was the most symptom. Overall, reactions to GBCA are extremely rare but its safety could be enhanced being aware of some demographics parameters.

Keywords

abnormal according accounting active administration adverse agent agents allergic altered analyzed audience available babies bias care cause coded college common contrast country criteria damage database date death decade disability distribution divided dizziness drug elderly enhance enhanced even event events exams excluded excluding extraordinarily feeling female females fewer fibrosis flushing fold food gadolinium gastrointestinal gender health hospitalization hospitals hypersensitivity identified identifying immediate immune impairment incidence include injection interestingly intervention irritation lethal life like male males manual march martin media medical mental nasal nausea nearly occurring outcome outcomes overall pain patients peak permanent possibly predominance prevent previous primary prince problems professionals radiology ranging rash reaction reactions reduced reflecting related relational remaining report reported reporter reporting required respiratory retching reviewed risk safe safety sensation similarly site software status substantially suspect swelling symptom symptoms system systemic table target though threatening throat twice types urticaria utilizing varied version vomiting year years