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Abstract #0714

Decreased Retinal and Choroidal Blood Flow by MRI Is Correlated with Electroretinography in Retinitis Pigmentosa

Yi Zhang1, Joseph Harrison2, Oscar San Emeterio Nateras1, Steven Chalfin2, Timothy O. Duong1, 2

1Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States

Retinitis pigmentosa (RP) is a heterogeneous hereditary disease characterized by photoreceptor degeneration and retinal pigment deposits. Altered ocular blood circulation has been implicated in the degenerative process and/or the pathogenesis of RP. This study demonstrates a novel MRI approach to study the circulatory changes associated with RP in unanesthetized humans. MRI indicates significantly reduced blood flow (BF) in RP retina with a strong link to its suppressed electroretinogram responses.

Keywords

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