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Abstract #0689

Soleus Muscle Water T2 Values in Duchenne Muscular Dystrophy: Associations with Age and Corticosteroid Treatment

William D. Rooney1, Sean C. Forbes2, William Triplett3, D-J Wang4, James Pollaro1, Soren DeVos2, Rebecca J. Willcocks3, Richard Finkel5, Barry Russman6, Barry Byrne7, Lee Sweeney8, Glenn A. Walter3, Krista Vandenborne2

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2Department of Physical Therapy, University of Florida, Gainesville, FL, United States; 3Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, United States; 4Radiology, The Childrens Hospital of Philadelphia, Philadelphia, PA, United States; 5Neurology, The Childrens Hospital of Philadelphia, Philadelphia, PA, United States; 6Neurology, Oregon Health & Science University, Portland, OR, United States; 7Department of Pediatrics, University of Florida, Gainesville, FL, United States; 8Department of Physiology, University of Pennsylvania, Philadelphia, PA, United States

The purpose of the study was to investigate the age dependence of MRS water proton qT2 values in healthy control boys and boys with DMD. Data were acquired from 83 DMD boys and 22 healthy controls on 3T MRI instruments at three institutions. 1H MRS data were acquired to estimate 1H2O T2 using a STEAM single voxel located in the soleus muscle. 1H2O T2 values were significantly increased for DMD boys and decreased with age. Corticosteroid treated DMD boys had a lower 1H2O T2 than untreated DMD boys.

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Keywords

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