Meeting Banner
Abstract #0651

Non-Contrast-Enhanced Preoperative Assessment of Lung Perfusion in Patients with Non-Small-Cell Lung Cancer Using Fourier Decomposition Magnetic Resonance Imaging

Gregor Sommer1, 2, Michael Puderbach3, Marcel Koenigkam-Santos3, 4, Christopher Draenkow5, Claus-Peter Heussel3, Hans-Ulrich Kauczor6, Heinz-Peter Schlemmer2, Grzegorz Bauman7, 8

1Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland; 2Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; 3Radiology, Thoraxklinik Heidelberg, Heidelberg, Germany; 4Radiology, University Hospital of the School of Medicine of Ribeirao Preto - University of Sao Paulo, Ribeirao Preto, Brazil; 5Surgery, Thoraxklinik Heidelberg, Heidelberg, Germany; 6Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany; 7Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany; 8Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States

This study investigates non-contrast-enhanced Fourier decomposition MRI (FD MRI) as a tool for preoperative assessment of regional lung perfusion in 15 patients with NSCLC against dynamic contrast-enhanced MRI (DCE MRI). FD MRI provides high sensitivity (84%), specificity (92%) and accuracy (91%) in detecting lobar perfusion defects. Image quality of FD MRI has shown to be less than that of its reference DCE MRI. FD MRI can quantify bilateral and lobar perfusion proportions with sufficient accuracy in both upper lobes and for bilateral comparison, but is in its present form limited by pulsation artifacts in the lower parts of the lungs.

Abstract PDF

Keywords

absolute accuracy address agreement analyzed applicable arrows arterial artifacts assessment asterisks bias bilateral bland blood cancer capability cardiac caused causing cell cine clinical coded cohorts common contrast coronal corrected correlation created curative cycles dashed decomposition defects density detect detecting diagnostic diagrams disorders dynamic encoded enhanced entire extends feasible fissure flow form function functional good highest horizontal hospital hotel identified included individual inferior introduced investigation knowledge larger limits linear lobar lobe lobes lung lungs manual mass matching measured medical medicine middle minor must native nuclear optimized optimizing original outcome overall parts patients perfusion periodic peter physics plot porcine predicting preexisting preoperative proportions prospectively proton pulmonary pulsation quality quantify quantitative radiology readers reformatted regional registration remaining resolution resolved respiratory revealed rigid routine school section segmentation sensitivity significantly specificity spectral stochastic subsequent subtraction sufficient surgery surgical thereby towards trajectories treatment tumor upper validated variational velocity ventilation vision visual visually volume woman women workshop year