Meeting Banner
Abstract #0636

Multi-Component T2 Analysis of Articular Cartilage with Synovial Fluid Partial Volume Correction Using McDESPOT at 3.0T

Fang Liu1, Samuel A. Hurley1, Alexey Samosonov1, Andrew L. Alexander1, Sean C. L. Deoni2, Walter F. Block1, 3, Richard Kijowski4

1Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2Division of Engineering, Brown University, Providence, RI, United States; 3Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States; 4Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States

Multi-component T2 mapping using mcDESPOT three pool model was performed for correcting synovial fluid partial volume contamination in human knee cartilage in-vivo scan at 3.0T. T2 relaxation time for the bulk water loosely bound to the proteoglycan matrix (Wb) were shown to be mostly affected at the superficial layer of the cartilage with increasing T2 values more than 100% compared to the deep layer. mcDESPOT three pool model shows significant advantage of correcting the T2 relaxation time estimation bias while has no influence on measurements within the remaining portions of the cartilage.

Abstract PDF Presentation Video

Keywords

able abstract account accurate acknowledge additional address adult although analyzed approximately array arrows articular averaging axial balanced bias biomedical block bone bound brown bulk calculating cartilage cause caused channel characteristics chemical close coil collagen component components conducting considered consist correcting correction covering cycling deeper derived designed despite determine discovery division driven engineering entire equilibrium estimation examination exchange excitation extra extremity fails fang feasibility field finding fluid fraction free fully fund future generally gradient gratefully healthy house human ideal included incorporating indicating influence influenced instead intentionally introduces inversion investigate involves joint knee layer loosely macromolecule macromolecules maps marrow matrix medical minutes model modeling models multicomponent necessary notice observation overestimated partial patella physics pool portions potential potion precession previously problem program promising providence pulse quantitative radiology reconstructed reconstruction recovery remaining remove removing scanner series severe slice source spoiled static steady superficial support suppression termed tightly view visible volume volunteer water white zero