Meeting Banner
Abstract #0591

Free-Breathing Vs. Breath-Hold Pulmonary Perfusion MRI: Quantification and Reproducibility

Michael Ingrisch1, Daniel Maxien1, Felix Schwab1, Maximilian F. Reiser1, Konstantin Nikolaou1, Olaf Dietrich1

1Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital, Munich, Germany

Pulmonary perfusion can be assessed with a DCE MRI measurement which is usually performed during breath hold. However, pulmonary perfusion depends strongly on the phase of the breathing cycle during which breath hold is performed. This leads to a poor reproducibility of quantitative estimates of pulmonary perfusion. Since it was recently demonstrated that pulmonary perfusion can also be assessed from a measurement during free breathing, this volunteer study therefore investigates whether an acquisition during free breathing, which also has a better patient compliance, leads to parameter estimates with a better reproducibility than an acquisition during inspiratory breath hold.

Keywords

accelerated acquiring acquisition acquisitions advantage agent anterior articular assess assessed assessment audience automatically better breath breathe breathing cartilage chest class clinical coefficient coefficients compartment compliance consent contrast conventionally correlation curve cycle datasets determined diaphragm diffusion disease displayed dose dynamic elaborated elastic eliminating enrolled entire even examinations expiration fact feasibility fink flow free halves healthy history hold holding hospital ignored improved in vivo included increasing indicated indicates influence informed inherently injected injection inspiration instead institute instructed intra invest investigate known leads least lung male maps matrix median medical mentioning might mild minimize model motion noise paired parametric patient perfusion physicists pixel plasma post posterior potential previous processing properties pulmonary quantification quantitative radiologists radiology rank reason recently registration reproducibility residual resolution retest retrospective segmented separated shallowly sided signed significantly simultaneously square started statistical strongly substantially suitable supp symptoms system table target temporal thereby throughout tissue triggering twice variation varies volume volunteer volunteers whether worth yield