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Abstract #0503

Amide Proton Transfer MRI Evaluation of Bladder Cancer Neoadjuvant Chemotherapy

Guang Jia1, Huyen Thanh Nguyen1, Kamal S. Pohar2, Amir Mortazavi3, Zarine K. Shah1, Lai Wei4, Michael V. Knopp1

1Department of Radiology, The Ohio State University, Columbus, OH, United States; 2Department of Urology, The Ohio State University, Columbus, OH, United States; 3Department of Medical Oncology, The Ohio State University, Columbus, OH, United States; 4Center for Biostatistics, The Ohio State University, Columbus, OH, United States

This study was conducted to evaluate the role of APT-MRI in bladder cancer neoadjuvant chemotherapy response assessment.

Keywords

adjusting allowing amide analyzed application appropriately approval artifact assess assessment asymmetric backbones biostatistics bladder block board cancer cancerous cellular characterization chemical chemotherapy clinical commonly compliant composed concentrations constant covering cycle cycles decrease decreased decreases dedicated defined depict detectable detection determined diagnosed differentiate disease duration efficacy elevated emerged endogenous evaluate evaluated exchange exhibited exhibiting facilitate facts field frequency goal greater grow improve improving included increasing induced informed institutional intensity interval lesions little lymph mapping marker materials medical metastasized mobile molecular months motion multiplicity node novel oncology outcomes overall patient patients peptide period placement possibly press primary prior progress progressive promising protein proteins proton protons pulse pulses quantification quantify radical radiology received remaining respond responder responders response revealed review saturated saturation seminal shah shot significantly sixteen slice spectra stable subtracted successful surgery suspected system therapy thin tissues train transfer transverse trial trials tumor tumors typical undertaken urology uterus vesicles wall water whether written