Meeting Banner
Abstract #0461

Exchange Rate Selective Imaging Using T1&[rho] Dispersion

John T. Spear1, 2, Zhongliang Zu2, 3, John C. Gore, 3

1Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States; 2Vanderbilt University Institute of Imaging Science, Nashville, TN, United States; 3Department of Radiology, Vanderbilt University, Nashville, TN, United States

A novel technique is explained for producing chemical exchange rate dependent images and describes how to analyze these images to calculate exchange rates for model systems. Samples containing Glucose and Creatine were imaged and analyzed to calculate exchange rates of 5,750 Hz and 499 Hz respectively, which are reasonably close to previously reported values in the literature. This technique can theoretically be extended to calculate exchange rates of separate pools in mixtures as well, which will be of great interest moving forward.

Keywords

according alto always amplitude amplitudes analyzed appropriate assuming astronomy audience behavior characterization characterize chemical choosing close combined compute consider contrast contrasts contributions corresponds curve curves deconvolve define denote dependent depends derived deriving described developed differently dispersion dominated dotted either emphasize emphasized ensure equation equations every exchange exchanging exhibited explicitly expression extended fast field fields fitting form fractional fractions frame frequencies frequency function glucose gore identify identifying in vivo inflection institute intensities intensity intermediate investigators john judiciously known labile lattice least literature lock locking magnitude matrix maximize measure mechanisms media metabolite mixture mixtures note novel peak peaks physics pixel pool pools population potential practical practice prepared principle produced proposed protons quantifying quantitative radiology rather reasonably reflecting regime represents respectively sample samples science selected selective selectively sensitive separate sigma simplified simulated spear species spectroscopic spin squares strengths subsequently suited systems take taken target theoretically tissue transverse type utilizing valid variation varying volume water whereas yield