1Department
of Applied Physics, University of Eastern Finland, Kuopio, Finland; 2Department
of Radiology, University of Oulu, Oulu, Finland; 3Department of
Diagnostic Radiology, Oulu University Hospital, Oulu, Finland; 4Institute
of Biomedicine, Anatomy, University of Eastern Finland, Kuopio, Finland; 5Department
of Medical Technology, University of Oulu, Oulu, Finland; 6Department
of Anatomy and Cell Biology, University of Oulu, Oulu, Finland; 7Center
for Magnetic Resonance Research, Department of Radiology, University of
Minnesota, Minneapolis, MN, United States; 8Department of
Orthopaedic Surgery, University of Minnesota, Minneapolis, MN, United States
The purpose of this study was to evaluate cartilage-bone interface in osteochondral samples from human tibia with varying degrees of degeneration using SWIFT. For reference, micro-computed tomography (micro-CT) imaging, histopathological scoring (OARSI) and histological evaluation were used. Differences in the appearance of the calcified cartilage and subchondral bone were detected with SWIFT, depending on the degree of OA. SWIFT was capable of elucidating tissue changes associated to the degree of OA.