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Abstract #0380

Brain Softening - A Hallmark of Neurodegeneration: Cerebral MR Elastography in Patients with Supranuclear Palsy and Idiopathic Parkinsons Disease.

Ingolf Sack1, Axel Lipp2, Radmila Trbojevic1, Friedemann Paul3, Andreas Fehlner4, Sebastian Hirsch1, Michael Scheel1, Cornelia Noack2, Jing Guo5, Dieter Klatt1, Jens Wuerfel3, Juergen Braun6

1Department of Radiology, Charit - Universittsmedizin Berlin, Berlin, Germany; 2Department of Neurology, Charit - Universittsmedizin Berlin, Berlin, Germany; 3Neurocure, Charit - Universittsmedizin Berlin, Berlin, Germany; 4Department of Radiology, Charit University Medicine, Berlin, Germany; 5Department of Radiology, Charite - University Medicine Berlin, Berlin, Germany; 6Institute of Medical Informatics, Charite - University Medicine Berlin, Berlin, Germany

2D-multifrequency MRE and 3D-MRE was used to assess the sensitivity of cerebral viscoelastic properties for discriminating two neurodegenerative disorders with overlapping clinical presentation, but different underlying neuropathology -namely progressive supranuclear palsy (PSP, N=16) and idiopathic Parkinsons disease (PD, N=18) in comparison to healthy controls (N=18). We observed a close negative correlation between MRE constants and measures of clinical severity in PD and PSP. Moreover, we showed that brain viscoelasticity in PSP and PD is differently affected; whereas in PSP all MRE constants are reduced, changes in PD are limited to declining elasticity parameters.

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Keywords

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