Meeting Banner
Abstract #0340

Effect of Normobaric Hyperoxia (NBO) on Progression of Ischemic Stroke

Yash Vardhan Tiwari1, Fang Du1, Qiang Shen1, Timothy O. Duong2

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States

We used quantitative MRI to longitudinally evaluate the effects of normobaric hyperoxia (NBO) treatment on the outcome of ischemic stroke in rats. The major finding is that NBO treatment decreased infarct size by 27.4 % compared to control at day 2. NBO treatment stopped ADC lesion growth at the acute phase, thereby delaying the progression of ischemic penumbra to ischemic core. With reperfusion, substantially more tissue was salvaged compared to controls. The implication of these findings is that NBO can be used to buy time and expand the treatment time window in stroke patients

Keywords

acute administered analyzed apparent artery audience became behavioral blinded blood brain cascades cell cerebral chronic coefficient concentration concluded control controls core correction cortex cost critical damage days death decreased defined delaying depolarizations derived described detrimental diffusion double doubles durations edema effective elsewhere emergency evaluate evaluated except expand experiment experimental fang final finding findings flow free future grew growth hand health hemoglobin herein hours hypothesis improves included infarct inflammatory inhibits initial institute investigate journal larger laser leads lesion longitudinally major male many maps measured minutes model models monitor neurology neurosurgery occlusion occurrence offers outcome oxygen paired paper penumbra percentage plays post primary processes production progression quantitative radial randomized rats readily received reduce reduces researchers responders reversed role science secondary sensitive several shin significantly slightly smaller speckle stabilizes statistically stopped stroke studies subjected substantially taken target tension texts therapy thereby throughout timothy tissue transient translational treated treatment treatments unique unpaired volume volumes window