A Modified Photothrombotic Stroke Model Using Implantable Optic Fiber: In-Bore Stroke Induction for Probing Peri-Infarct Spreading Depolarization

Keywords

accelerate acute adding administered aimed allowing animal appear appears around artery attempt axis bandwidth biomedical bore brain capable cerebral chapel characterize clearly clinically coded coil compatible continually continuous contrast controlled core cortex courses creating declined decrease delay demand dental depolarization depth described develop diffusion dose dropped duration either electric energy established every experimental fiber fibers final fisher functional future hill home homeostasis hyperemia identical identification illumination implantable implantation implanted implanting inaccessible induction infarct inset inside interleaved intravenously investigate knowledge known labeling laser lesion lesions localized location made male maps measured model models modified neurological neurology next nucleus occurs onset optic optical outcome paralyzed patch perfusion plot post potential predetermined previously processed propagated propagating proposed quantitative rats reached reduce reduced relatively relevant reported resolution respectively rises rodent rose scale scanner separate series session sharp shin shot speed spin spreading stain statistical steady stroke subject surface tabulated target temporal territory third treatment waves