Functional and Structural Connectivity Impairments Precede Plaque Deposition in a Transgenic Mouse Model of Alzheimers Disease

Keywords

aged aging alteration alterations animals anisotropy array aspects auditory bars basal bilateral brain cerebral coefficient cognition coil computed connectivity containing controls corpus corrected correction correlation correlations cortex cortices coupling cryogenic declining decrease decreased density deposition detectable detected develop development deviation diffusion dimension discovery disease distance done drift duration early elsewhere encoding equipped error explain face false fiber find forceps fractional frequency functional ganglia gender general genetically genotype house impaired impairments increasing indicated induced inst institute interestingly intracellular leading mask matrix measure mice minor mixed model models months motion motor mouse nerve network normalized occurred oxygen pairs panel parts pathology persisted pharmacology pixel plaque precede progressed progressively question reaching realigned reduced reduction regressed related remain repetitions reproducible response responses resting retraction reveal revealed reveals rich sensory several severity significance significantly slice slices stages statistical statistically stimuli structural studies suggesting system template throughout timing toxicology translates type unchanged upper variables visual whether wild