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Abstract #0298

BOLD fMRI Study of Rat Inferior Colliculus Activated by an Oddball Paradigm

Patrick P. Gao1, 2, Jevin W. Zhang1, 2, Joe S. Cheng1, 2, Russell W. Chan1, 2, Leon C. Ho1, 2, Iris Y. Zhou1, 2, Ed X. Wu1, 2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong SAR, China

Rapid detection of sudden changes of external sensory stimulation is important for interaction with environment. In auditory neuroscience, the oddball paradigm has been frequently used to investigate how sounds are processed in different cortical and subcortical structures. Most human studies were focused on the cortical regions while recent electrophysiological studies in animals revealed that neurons in subcortical regions also respond to novel stimulus. In this study, we aim to reveal the role of rodent inferior colliculus in processing novel sounds non-invasively using BOLD fMRI.

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Keywords

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