The Fixation Protocol Alters Brain Morphology in ex-vivo MRI Mouse Phenotyping

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administered affect affects align aligned allowing alters analyses another audience automated become biophysics blue brain buffered calculations cautionary characterize characterized chemical children close common compensate confidence confounding consensus consequently containing coronal cross days decreased decreases deformation dependent described despite detectable determinant determine diagnostics discovery ducts echoes eight exact expansion fast fields final fixation fixative free front head heparin highlighting histological hour hours identifying in vivo included inconsistent increasing indicated individual initial inside intercept intervals investigation least length linearly long masquerade matrix medical morphological morphology mouse note occurs pattern percent perfusion period permeability placed play plotted popular post practice preparation preserve prevent previously process project protocol protocols random registration regularly removal resolution role saline sample samples scale segmented shepherd sick skull slices slope soaked sodium solution spacing statistical statistically storage structure structures studies subject taken target term third tissue transferred underwent uniform variability varies variety vary varying ventricles volume volumetric washed whose wide yield