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Abstract #0236

MR Imaging of Cancer Vasculature Using VEGF Receptor-Targeted Dual Contrast Labeled Liposomes

Yoshinori Kato1, 2, Wenlian Zhu1, Marina V. Backer3, Ronnie C. Mease, 14, Susanta K. Sarkar5, Joseph M. Backer3, Dmitri Artemov1, 2

1JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 3SibTech, Inc., Brookfield, CT, United States; 4Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 5Translational/Clinical Imaging, Sanofi Oncology, Cambridge, MA, United States

Molecular imaging of cancer vasculature via vascular endothelial growth factor receptors (VEGFR) can be important for image-guided drug delivery and for evaluation of the efficacy of anti-angiogenic therapy. Single-chain VEGF (scVEGF)-decorated liposomes loaded with GdDTPA and superparamagnetic iron oxide (SPIO) can serve as a theranostic (therapeutic and imaging) platform that provides targeted delivery of therapeutic agents and MRI probes to tumor vasculature, and simultaneous monitoring of the stability of the carrier. Unique MR contrast enhancement patterns can reliably report the delivery of intact carriers to the target site and the release of the therapeutic cargo.

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Keywords

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