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Abstract #0214

in vivo Spectroscopic Imaging of 2-Hydroxyglutarate in Human Gliomas at 7.0 T

Sandeep Ganji1, Keith M. Hulsey1, Elizabeth A. Maher2, 3, Changho Choi4

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 2Harold C. Simmons Cancer Center,, UT Southwestern Medical Center, Dallas, TX, United States; 3Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States; 4Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

We report the first in vivo spectroscopic imaging of 2HG at 7T using an optimized echo-time PRESS-based localization method in subjects with brain tumors. We present phantom and in vivo data and show the elevated 2HG levels in tumor patients. Metabolites concentration maps are also presented.

Keywords

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