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Abstract #0204

The Robustness of DSC-PWI for Acute Stroke Imaging; Timing Is Everything: The Vanishing Perfusion Abnormality.

Irene Klaerke Mikkelsen1, Lars Riisgaard Ribe1, Susanne Lise Bekke1, Kim Mouridsen1, Leif stergaard1

1Center for Functionally Integrative Neuroscience, Aarhus University Hospital, Aarhus, Denmark

In patients with acute ischemic stroke, millions of neurons die by the minute. For those who are eligible for thrombolytic therapy, the duration of diagnostic DSC-scans are therefore reduced to a minimum. This study shows that this practice may lead to severe underestimation of the perfusion abnormality, and therefore the therapeutic target. The degree of underestimation is investigated for three different deconvolution techniques.

Keywords

abnormality acquisitions actual acute addition additional apparent appear approaches arrival arterial assumptions automatically background bolus bottom chosen conditions consensus contrast curve curves deconvolution defined degree dependent describe detect determined diagnostic duration durations earlier eligible especially everything evident examined example exceed explain faster free frequency full function functionally general hospital inferring inherent injection input integrative intensity investigated lateral latter lead least length lesion lesions make maps marked meanwhile measured metrics middle millions minute model need neurons noise normalized note operationally outlined overlooked parametric patient patients peak perfusion poor poorly practice priori priors ranging reach reached reasonable recommend recommended reduced referred required residue response robust robustly robustness semi sensitive short shortest side slice smooth squares stop stroke subtracting suited target therapeutic therapy thought timing tissue truncation underestimation upper vanishing variability vascular visible volume