Meeting Banner
Abstract #0114

Early Increases in Glu/Gln, Tau and TCho 1H MRS Resonances in vivo, Anticipate Later Imaging Repercussions of the Cerebral Inflammatory Response in a Mouse Model of LPS-Induced Endotoxemia

Ana Belen Martn-Recuero1, Agnieszka Krzyzanowska2, Pilar Lpez-Larrubia1, Carlos Avendao2, Sebastin Cerdn3

1Laboratorio de Modelos Animales, Instituto Investigaciones Biomdicas Alberto Sols CSIC-UAM, Madrid, Spain; 2Anatomy, Histology & Neuroscience, Medical School, Autonoma Univ. of Madrid, Spain, Madrid, Spain; 3Laboratorio de Modelos Animales, Instituto de Investigaciones Biomdicas - CSIC, Madrid, Spain

Cerebral inflammation underlies the most morbid and prevalent neurological disorders, including cancer, ischemia or neurodegeneration. However, the inflammatory component remains difficult to differentiate from the intrinsic pathology by most bioimaging methods, since in-vivo biomarkers of the inflammatory phenotype have not been characterized. With this aim, we report a longitudinal MRI and MRS characterization of the cerebral inflammatory component developed after systemic administration of LPS, an inflammation model devoid of additional intrinsic pathologies. Our results revealed that inflammation is characterized by early, severe, spectroscopic changes in Glu/Gln, tCho, Tau and Lac resonances, anticipating those detected later by multi-parametric MRI.

Abstract PDF Presentation Video

Keywords

able administration altered analyses anatomy anti anticipate apparent appear around augmented basal became blue brain cancer cerebral characterization characterize choline clearly coefficient component components computed concomitant confirmed consequences considerable contribution cortex cortical cryostat days decreased detectable detected developed development diagnostic difficult diffusion disappearing discriminate disorders early entails evaluate evaluation exclusively fems finally glutamate green grounds histological histology house identify immediately in vivo indicate induced inflammation inflammatory injection insult invasive investigated just knowledge lactate limit lipids longitudinal macromolecules magnetization magnitude making male many maps mart maximal measured medical metabolic metabolism metabolites mice model mouse neurological notably paired panel parametric park peak perfused posterior precede press prevalent previously probably proceeds purple quantified reactive received recovered reflecting repercussions report representative represented response responses revealed reveals scanner school sections selected severe shock significance significantly slightly software sols spectra spectroscopic spectroscopy statistical statistically strategies student studies subjects suffer suggest systemic therapeutic thick third transfer triggered univ upper variations