Meeting Banner
Abstract #0100

Planning a Boosted Radiotherapy Dose to the Dominant Intraprostatic Tumour Lesion Within the Prostate as Defined by Multifunctional MR Parameters

Sophie F. Riches1, Geoffrey S. Payne1, Nandita M. deSouza1, Scott Morgan2, David Dearnaley3, Veronica A. Morgan1, Sharon L. Giles1, Mike Partridge4

1CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 2Division of Radiation Oncology, University of Ottawa, Ottawa, Ontario, Canada; 3Division of Radiotherapy & Imaging, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 4Gray Institute for Radiation Oncology and Biology,Department of Oncology, University of Oxford, Oxford, Oxfordshire, United Kingdom

The use of a boosted radiation dose to a tumour nodule within the prostate is limited by poor accuracy for tumour localisation on morphological imaging; functional imaging offers more accurate delineation of the dominant intraprostatic lesion. This study uses a model that combines multifunctional MR parameters to define an intraprostatic lesion and plans an 84 Gy radiation boost to functional imaging-defined tumour with IMRT. Compared to a standard clinical treatment of 72 Gy applied uniformly across the prostate, a focal boost resulted in a greater therapeutic ratio, with potentially greater tumour control and fewer side-effects from the treatment.

Abstract PDF Presentation Video

Keywords

abstract account achievable achieving advantages allowed allowing anatomical applied audience biology black bladder body boost boosted cancer clinical clinically clinicians coil combined comparing complication compromising confidence constraints constructed contrast control course curve dashed decreases define defined deliver deliverable delivered delivery determined diffusion division dominant dose dynamic enhanced entire feasibility fewer focal foundation fractional functional gray greater histograms hormone identifiable identified immediately implanted improved indicate institute interim intra investigate investigating kingdom lesion lesions limitations limits linear location longer maintaining mandatory maps mike model month oncology onto optional outline oxford paired parametric partridge patients physicists place plan planning plans positioning possibly post potentially predicted previously prior probabilities probability prostate proton radiation radiotherapy rectal rectum register registered registration replicate requirement rest revealed riches rigid royal scaling shrinkage side significantly spectroscopic started structures submitted surrey surrounding target therapeutic therapy tissue tissues toxic translated treatment trust undergoing unexpectedly uniform uniformly validated veronica volume whilst zero