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Abstract #0053

Combining ZOOPPA and Blipped CAIPIRINHA for Highly Accelerated Diffusion Weighted Imaging at 7T and 3T

Cornelius Eichner1, 2, Kawin Setsompop2, 3, Peter J. Koopmans4, Alfred Anwander1, Ralf Ltzkendorf5, Steven F. Cauley6, Himanshu Bhat7, David G. Norris4, Robert Turner1, Lawrence L. Wald2, 3, Robin Martin Heidemann1, 8

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 2Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 3Harvard Medical School, Boston, MA, United States; 4Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands; 5Otto v. Guericke University, Magdeburg, Germany; 6Massachusetts General Hospital, Charlestown, MA, United States; 7Siemens Medical Solutions, Malvern, PA, United States; 8Siemens Healthcare Sector, Erlangen, Germany

The ZOOPPA technique provides highly resolved dMRI data at 7T, but whole-brain data sets take a long time to acquire. EPI volume acquisition time can be greatly reduced using blipped CAIPIRINHA. We have implemented combined ZOOPPA and CAIPIRINHA, enabling highly resolved and accelerated acquisition of dMRI data at 7T.

Keywords

accelerated acceleration achieve achieved acquisition adapted address aims allow amplitude anatomical angular applications become benefit better biomedical blipped body brain broad calibration chem cognition cognitive coil combination combine combined combining comparable constraints datasets decay deconvolution deposition designed diffusion dimensions distortions done element employ enables energy enough exactly excitation excited fast feasible fiber field full function functional gain generated give gradient head highly hindrance hour human in vivo institute interspersed isotropic limitation limited limiting limits long major mandatory medical might minutes modeled necessary noise note nova object orientations overall parallel particularly peak penalty periodic phys pins problem product profiles promising pulse pulses recently reconstruction reduce reduced refocusing required resolution restriction robin school sciences sector sensitivities sensitivity session short shorten shortened shorter significantly simultaneous simultaneously slab slew slice slices solutions spacing spatial specified speed streamline strength strengths stronger studies system table tanner theoretically tracking trans turner typically ultra unfolded unfolding unlimited useful whole words zoomed