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Abstract #0006

Regional Mapping of Gas Uptake by Red Blood Cells and Tissue in the Human Lung Using Hyperpolarized Xenon-129 MRI

Kun Qing1, Kai Ruppert2, Yun Jiang3, Jaime F. Mata2, G Wilson Miller2, Yun Michael Shim4, Chengbo Wang2, Iulian C. Ruset5, 6, F. William Hersman5, 6, Talissa A. Altes2, John P. Mugler, III1, 2

1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; 2Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States; 3Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 4Medicine, Pulmonary and Critical Care, University of Virginia School of Medicine, Charlottesville, VA, United States; 5Xemed LLC, Durham, NH, United States; 6Physics, University of New Hampshire, Durham, NH, United States

We have demonstrated an imaging method that permits regional mapping of the tissue and RBC fractions of Xe129 dissolved in the human lung, as well as quantitative comparison of tissue- and RBC-based ratios among subjects. The 11-sec breath-hold acquisition was well tolerated by both healthy volunteers and subjects with obstructive lung disease. Our preliminary results, although obtained from a small number of subjects in this exploratory study, suggest marked differences in the spatial distributions of Xe129 dissolved in tissue and RBCs among healthy subjects, smokers (including those with COPD), and asthmatics.

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Keywords

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