Meeting Banner
Abstract #4460

B1-Dependence of Single-Voxel MRS Sequences: STEAM, PRESS and MEGA-PRESS

Nicolaas AJ Puts1, 2, Michael Schr, 13, He Zhu1, 2, Peter B. Barker1, 2, Richard AE Edden1, 2

1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States; 2FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3Philips Healthcare, Cleveland, OH, United States

In this abstract, we investigate the extent to which 3 single-voxel MRS sequences (STEAM, PRESS and MEGA-PRESS) are sensitive to miscalibration (or inhomogeneity) of the B1 field. Experimental results at 7T show that the actual B1 dependence is much worse than a naive model of sin dependence for excitation pulses and sin-squared for refocusing. For MEGA-PRESS, even a 20% drop in B1 can result in over 50% loss in signal.

Keywords

abstract accounted accurate achievable actual although application applications assumed assuming asymmetric bandwidth barker behavior best brain brought buffered calibration careful challenge chemical common coverage critical curves deliver dependence dependent depends describing detected determines dispersion especially even excitation exotic expectations expected expects experiment experimental expressions field functional functions funding global goes good greater half homogeneity impact important improved increasing increments independently inhomogeneity inhomogeneous institute integral intended intensity interaction issue issues johns like localization localized localizes loss maintain major matched measured mega often optimum orthogonal output parallel particular peak pertinent peter phantom phosphate power predict predicted press profile profiles progress progressively pulse pulses puts quantification radiological radiology rather rectangular refocusing saline sampling scaled scanned scanner science selection selective sensitivity severity shaped shapes simple simulated simulation simulations sine slice solution spatial spectral steam strengths sufficiently supported suppression theory transmit typically underlined upon variation volume water whereas wider width worsening