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Abstract #4446

Reduced Motor Cortex GABA in Amyotrophic Lateral Sclerosis

Bradley R. Foerster1, 2, Brian C. Callaghan3, Myria Petrou1, 4, Richard AE Edden4, Thomas L. Chenevert1, Eva L. Feldman3

1Department of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor, MI, United States; 2Ann Arbor VA Healthcare System, Ann Arbor, MI, United States; 3Department of Neurology, University of Michigan, Ann Arbor, MI, United States; 4Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States

In this study, we investigate whether there are in vivo differences in GABA in the motor cortex and subcortical white matter of amyotrophic lateral sclerosis (ALS) patients compared with healthy controls. In 10 patients with ALS and 9 age- and sex-matched healthy controls, 3T edited proton magnetic resonance spectroscopy was performed to quantify GABA in primary motor cortex and subcortical white matter.

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Keywords

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