Meeting Banner
Abstract #4444

Magnetic Resonance Spectroscopy in Obsessive-Compulsive Disorder: Comparing Brain Metabolism in Selective Serotonin Responders and Non-Responders

Mona Adel Mohamed1, Richard Edden1, Manuel Uy2, Gerald Nestadt3, Peter Barker1

1Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, United States; 2Applied Physics Laboratory, Johns Hopkins University, Baltimore, MD, United States; 3Psychiatry, Johns Hopkins Medical Institutions, Baltimore, MD, United States

Through magnetic resonance spectroscopy (MRS), significant differences were found in myoinositol (mI) concentrations in the anterior cingulate cortex (ACC) of OCD patients as compared to controls, as well as differences in OCD patients who respond to selective serotonin reuptake inhibitors (SSRIs) and those who do not respond to SSRIs. Significant differences were also found in creatine (Cr) concentrations in the basal ganglia/Thalamus (BG/TH) region between the 2 groups. MRS can be a helpful tool in understanding of the pathophysiology of response to treatment which will lead to the development of new therapeutic approaches.

Abstract PDF E-Poster Video

Keywords

abnormal acknowledgment adults anterior applied approximately arch barker basal brain brown channel circuit clinical coil combined comparing compulsive concentrations control controls cortex determine determined development diminished disabling disorder disorders done dysfunction efficacy eighteen energy evaluation functional ganglia gender grant head health healthy illnesses improved included income inhibition inhibitor inhibitors inhibitory institutions johns laboratory lack lead life lost markers matched measured medical metabolism metabolites million month national obsessive older organization page patients people percent peter physics prevalence psychiatry quality radiology ranked relate related replication resistant respectively respond responders response review scale selective sense severity sought spectroscopy strategies student studies subjects suggested supported suppression survey system terms thalamus therapeutic treatment twenty understanding underwent water world year