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Abstract #4437

Three-Dimensional Multivoxel Proton MR Spectroscopy Distinguishes Regional Gray Matter Metabolic Abnormalities in SIV-Infected Rhesus Macaques at 3T: Initial Findings

William E. Wu1, Ivan Kirov1, Ke Zhang1, Eva-Maria Ratai

2, Chang-Gyu Joo2, R Gilberto Gonzalez2, Oded Gonen1

1New York University School of Medicine, New York, United States; 2Neuroradiology, Athinoula A. Martinos Center for Biomedical Imaging and Neuroradiology, Charlestown, MA, United States

Keywords

abnormalities absolute acute adult affect aids aligned although animal animals anterior axial basal bilaterally biomedical bottom boulder brain chemical choline circularly coil concentrations constant containing contamination content corpus described detected determining dimensional disease done elevation encoded entirely every excited fell females field findings fitted frame frequency functions ganglia general gray grid head healthy human hypothesis hypothesize identified infected infection initial intensity interleaved interpolated intervention invariably knee known least limitations macaque macaques male maria matrix medicine metabolic metabolite mitigate model modeling month months nominal oded optimization outlined overlaid overlapping parametric partial partially peak phantom pinpointing placement polarized poorly post posterior preliminary previously prohibitive protocol proton receive reducing regional related remain replacement rescanned resolution responses rhesus scaled scales school selectively simian slabs slice slices software spatial spectra spectral spectroscopy spin squares stages studies suffer supervision systems thalamus thereby thick transmit trio typical understood useful variably view volume vulnerable weeks white years yield zero