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Abstract #4418

Efficient Broadband Set-Up Using Travelling Wave and Strong Loading for Simultaneous Fluorine and Proton MRI at 7T

Anna Andreychenko1, Jim Craane1, Wouter Koning1, Peter R. Luijten1, Jan J.W. Lagendijk1, Cornelis A.T. van den Berg1, Dennis W.J. Klomp1

1Imaging Division, UMC Utrecht, Utrecht, Netherlands

Fluorinated drugs are frequently used in chemotherapy and can be monitored with Fluorine MRSI but reference proton MRI is needed. Use of double tuned coils is prevented by small difference in frequency between 1H and 19F spins. At 7T, a new transmit and receive RF concepts exploiting this small frequency difference can be applied. Waveguide concept with dielectric lining can be used to excite both nuclei. At 7T tissue load increases the bandwidth of receive coil and the same single tuned RF coil can detect both nuclei. Set-up with shared transmit and receive fields for proton/fluorine MRI was successfully demonstrated.

Keywords

absence accessible addition advantage agents allow analyzer applied array assessment banded bandwidth berg body broadband chemotherapy clinical closely coaxial coil coils combined combining complete compounds concept contrast curve cylindrical damping dashed detect detected detection dielectric differs distribution division double drug drugs efficacy efficient eight emphasize enables enabling excitation excitations field fields fluorinated fluorine frequencies frequency frequently great human illustrates impedances in vivo inclusion indeed input inside internal lining load loaded loading local loop loss matched metabolism metabolites middle minimally mode model monitored nature network noise optimal optimized outlined overall particularly patterns peter phantom pick placed positioned preamplifier prediction preventing principle probe procedures proof proton quadrature quantification quantitative receive received receiver receivers reduces related relatively respect restricted scaling scanner section settings side similarity simulations simultaneous since spin spins strength strong studies successfully sufficient surface switched thereby tissue torso toxicity transmission transmit transversal transverse treatment tumors tuned uniform verify water wave waveguide wavelength wide wolf