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Abstract #4393

Automated Partial Volume Calculation in Single Voxel 1H-MRS

Hedok Lee1, Elisabeth Caparelli2, Haifang Li3, Ruth Reinsel1, Amit Mandal1, David Smith4, Shaonan Zhang1, Helene Benveniste1

1Anesthesiology, State University of New York at Stony Brook, Stony Brook, NY, United States; 2Neuroscience Center, State University of New York at Stony Brook, Stony Brook, NY, United States; 3Radiology, State University of New York at Stony Brook, Stony Brook, NY, United States; 4Medical, Brookhaven National Laboratory, Upton, NY, United States

In proton magnetic resonance spectroscopy (1HMRS), partial volume effect is inevitable and substantial uncertainty is introduced in metabolite concentration calculations when water is used as an internal reference. The present study focuses on methodological aspects pertaining to mapping the 1HMRS voxel onto the corresponding anatomical scan and results are compared on the basis of positional accuracy, positional reliability, and metabolite concentration estimates. We found computerized or manual voxel placement methods are equally valid. We also found significant correlation between metabolite concentrations and GM tissue volume fractions confirming previous studies.

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Keywords

abundance acceptable accuracy agreement among analyzed anatomical anesthesiology approved aspects automated bandwidth basis binary body brook calculation calculations cancer cerebral chemical coarse coefficients composition compounds computerized concentration concentrations confirming consistent console controls corrected correlated correlation correlations cosines days depicts derived detection determined dice discrepancy display either enhancement evaluated evident excellent focused focuses fractions fusion grant healthy indicating inevitable internal introduced investigate investigated laboratory larger least lobe lobes longitudinal lung making manual manually mapping mask matrices medical metabolic metabolite metabolites methodological metric model national nearly occipital ongoing onto opportunities overlaps overlays paired parietal part partial participants patients pertaining placed placement positional positioning positions posse previous proton quantified radiology receiver reconstructed reconstruction relatively reliability repeated resolution respectively rotating scanned scanner scanners scanning screen session sessions significantly smith spatial statistically status stony studies subjects subsequently substantial supported targeted tissue transformation translating twice uncertainty underwent unsuppressed variance varying visit visits volume water whole years yielded