Meeting Banner
Abstract #4391

Reproducibility of Anterior Cingulate 1H MRS Data at 7T

S. Andrea Wijtenburg1, Laura M. Rowland1, Elena A. Spieker1, Richard A. E. Edden2, 3, Peter B. Barker2, 3

1Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States; 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States; 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

In this study, 7T spectroscopic data were acquired from healthy volunteers on two separate visits to determine the reproducibility of a short TE STEAM localization sequence. Voxels were placed in the anterior cingulate cortex, and all data were quantified using LCModel. Mean absolute differences were below 10% for most metabolites including GABA, suggesting that complex spectral editing techniques may not be necessary at higher field strengths.

Keywords

absolute academic achieved acquisition addition advantages affected allows anterior apart available bandwidth barker basis becoming believed brain calculations challenges channel chemical chosen coefficient coil complex concentration concentrations consistently correction cortex days determine diseases dispersion dominant duration eddy editing establish excellent expected female field fields fits frequency functional generated good head healthy homogeneous human identified important improved in vivo included influenced inhomogeneous institute institutional involvement johns knowledge laura leading localization localized male medical medicine metabolite metabolites necessary negatively neurological nova offer optimization others overlapping peaks perhaps peter placement poor power prior projection proof proton psychiatric psychiatry quantification quite radiological radiology reliable reported representative reproducibility residue sample scanned scanner schizophrenia school science selection separate separation shimming short since smaller spectra spectral spectroscopic spectroscopy spectrum steam strengths studies subjects suggest superior surprisingly susceptibility systems table technical transmit twice undertaking units variation visit visits volunteers water week widely