Kinetic Modelling of 13C Hyperpolarised Pyruvate Metabolism Using Measured Arterial Input Function in Tumours

Keywords

absolute actual administered administration allow animals applicable applied approximation arterial artery assumed automated best biochemistry biomedical blood bluff boxcar breathing built cancer carotid cell chamber choice clearly coil commonly comparable compatible complete conditions constant containing conversion corrected curve curves custom decaying determine determined develop direct either embedded enable error established estimation example exchange experimentally extract femoral fits fitted five flow function halted hence human hypothetical identification implanted influence initially injected injection injections injector input institute interconversion intravenous kinetic kingdom lactate living location mainly mathematical measured measures metabolism methodology middle might mixed model models monitoring oncology originated overestimates oxygenation portion potential precursor process product providing psychology pump quantifying rats relationship relatively representative required residence response robust sarcoma selection separate shapes site slice slices spectroscopy subcutaneously subsequently suggested suitable surface surrounding system tissue tissues treatment true typical underestimates validate validation variables venous viability weak whereas whether withdraw withdrawal