Meeting Banner
Abstract #4375

Monitoring Therapeutic Response on GBM in Chemotherapy by Amide Proton Transfer (APT) Imaging in Mice

MAGNA25Koji Sagiyama1, Osamu Togao1, Tomoyuki Mashimo2, 3, Kim Kangasniemi1, Vamsidhara Vemireddy, 34, Kimmo J. Hatanpaa5, Melissa A. Maddie, 34, Robert M.

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 2Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States; 3Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, United States; 4Department of Neurology, UT Southwestern Medical Center, Dallas, TX, United States; 5Departement of Pathology, UT Southwestern Medical Center, Dallas, TX, United States

Amide proton transfer (APT) imaging shows increasing interest in characterization of the brain tumor. The objective of our study is to investigate whether APT imaging can be used for monitoring treatment responses of the brain tumor in chemotherapy. In the present study, we compared the temporal changes of APT ratio in glioblastoma multiforme (GBM) in a mouse model with and without chemotherapy by Temozolomide which is widely used for the treatment of GBMs.

Abstract PDF E-Poster Video

Keywords

according acquisition affording amide anesthetized animal animals appearing applied approximately arrow asymmetry basis block brain brains called cancer cells chemical chemotherapy coil comprehensive confirm continuous control corporation corrected correction course culture cytoplasm days dean decrease decreased defined delineating detected developed directory distinguishing divided duration edge endogenous enlarged evaluation ever examination exchange fast final fitted fitting free frequency gradient grow harvested highly histology implantation infiltration inhibited inhomogeneity injected institution intensities interval investigate localizer maintaining materials matrix measured medical mice microscopic mitosis mixed mobile model monitoring mouse necrosis nuclei offset offsets oxygen paired pathology peptides percentage pixel polynomial population positioning post prevention previous procedure proteins protocol proton protons pulse radiation radiotherapy rapidly reconstructed recurrence reduced reflect repeated reported representative reproducible resolution respectively response responses rest revealed serially served session slice southwestern spectra spin student subjected suggests system temporal therapeutic tissue transfer treated treatment tumor tumors typical underwent useful wave weeks whereas whether widely