Semi-Quantification of LipoCEST CA in vivo. Application to Molecular Imaging of ανβ3 Integrins Expressed During Angiogenesis Using Targeted LipoCEST CA in a Tumor Mouse Brain Model

Keywords

accumulation achieving acquisitions actual adjustment affinity agent allows almost already amide analyzed animal application applied appreciate arguing aspect averaging bare better beyond binding blue brain bulk calibrated caudal cells challenging chart chem chemical chemistry cohort comparable compartment compatible concentration concentrations conditions consistent constants containing contrast control correct cost crucial curve curves days decrease detection determined developed distinct dots drug either enhancement equations errors establish exchange exogenous experimental exponential expressed fate favor feasible field fields fitting flow flowing function green human illustrated in vivo induced induction inhomogeneities injection intact interestingly introduced kinetics life longer macromolecular maps mice minimizing model modeling modest molecular monitored mouse nude opens peptide phantom plateau pool pools port post preceded precision processes promising protons quantification quantitative rapidly reached recently remains rodent saturation secondly semi sensitivity several simple simulated spectrum spite structure studies subjects taking target targeted thanks theoretical tool tout tumor typical validated validation vein vitro wash water whereas yellow