The Use of Fatty Acids with Hyperpolarized Pyruvate to Study Cardiac Substrate Metabolism in the Isolated Perfused Heart

Keywords

ability abstract achieve acid acids acquisition affecting albumin allow alone alternatives anatomy appear application assess assessed assessment ball balloon bicarbonate binding bolus bovine briefly buffer butyrate carbohydrate cardiac cardiovascular carried chain combined commenced compromising containing contractile council cycle decrease decreased delivered described developed direct disease either emulsion energetic energetics ensure enzyme experiment fatty find flux form foundation fuel fully function genetics glucose goal heart hearts ideal ideally in vivo independent inhibition inside instruments intensity investigate isolated kingdom leads locating long magnet measure mechanical medical metabolic metabolism metabolites minutes mode model molecular myocardium nuclear oxford oxidative oxygenated particularly pathways perfused perfusion physiological physiology placed plus polarization polyethylene potential preparation presence previous previously protocol proton prove providing rats recently recorded reduce reduces repeat represent respectively satisfactory serum setting shimming short significantly soluble solution source sources spectral spectroscopy stabilization subsequently successful successfully supported switched switching system throughout triglyceride uptake useful utilization variables ventricle ways whereby yield