Metabolic Response of Glioma to Dichloroacetate Measured by Hyperpolarized 13C MRSI

Keywords

acid active activity adult aggressive aimed appearing appears applied approximately assess assessment bandwidth bearing better bicarbonate brain brains breast bulk calculation cancer cell cells chemical chemotherapy clearly clinical coil combination concomitant consistently constants custom cycle days depending derives detecting detection differentiate differentiating difficult dissolution dissolved dual dynamic elevated enable enables energy enough especially even experiment feasibility flow flux glucose healthy highly illustrate implanted in vivo increasing infusion inhibiting inhibitor injected injection interleaves investigation label labeled laboratory lactate leading liquid mayer measured mediated merchant metabolic metabolism metric models natl nodal nominal nuclear optimized organs oxidative oxygen oxygenation park particular pathway pattern permitting polarization post prior process promotes prostate protocol proven quadrature quantitatively radiation rapid rats readily real received reception reduce reduction reflects remained representative respectively response retain scanner science sciences sensitive slice solid spatial spectra spin spiral step substrates survival tail therapy tissues towards tramp transplanted trials tumor tumors tuned variable varied veins whereas