Multi-Side Kinetic Modeling of 13C Metabolic MR Using [1-13C]pyruvate

Keywords

account accurate achieved acknowledges acquiring activity alanine allowed allows authors bars bias bicarbonate biochemical blood body calculation carbonic causing cellular chemical comparing complex concentrations confirmed consists content convergence conversion determination determined deviation diagram differential dissolution domain dominated done dose doses downstream dynamic dynamically equations error evaluated examined exchange exemplary experience exponential exposure extent fitting functions global gradient grant heart hydrate improved includes injection input integral integrals interaction interacts interdependency intravenous involved involving iterations kidney kinetic lactate least liquid liver male martin mass medicine metabolic metabolite metabolites modality model modeling models monitoring noise nuclear optimal pathways polarization potential predominant press previous process producing professional proposed publication quantification quantified rapid rats real reduced reflected represent representation represented represents responsibility robust saturation schematic selective semiquantitatively sense series side simulated simultaneously since slice slices smaller square squares statistically step subsequent suitable system take taken takes theory tissue tissues transaminase transient uptake useful validated yellow yielded