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Abstract #4295

Non-CPMG Echo-Train Sequence for T2 Mapping and Large SNR Gain in Hyperpolarized 13C Imaging

Yi-Fen Yen1, Sonal Josan2, 3, Lasitha Senadheera4, Jae Mo Park3, 5, Atsushi Takahashi1, Taichang Jang6, Milton Merchant6, Priti Balchandani3, James

1Global ASL, GE Healthcare, Menlo Park, CA, United States; 2Neuroscience Program, SRI International, Menlo Park, CA, United States; 3Dept. of Radiology, Stanford University, Stanford, CA, United States; 4Dept. of Radiation Oncology, Stanford University, Stanford, CA, United States; 5Dept. of Electrical Engineering, Stanford University, Stanford, CA, United States; 6Dept. of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States; 7Global ASL, GE Healthcare, Palaiseau, France

High resolution T2 mapping of hyperpolarized [1-13C]pyruvate and its metabolic products was accomplished by using a novel pulse sequence comprised of a non-CPMG echo train. Approximately 3-fold increase in signal-to-noise ratio (SNR) was obtained by averaging echo-train signals as compared to the SNR of the first spin-echo. This technique was demonstrated in vivo on normal rat liver, mouse prostate cancer model and rat glioma model.

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Keywords

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