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Abstract #4287

Correcting Patient Movement in Dynamic Contrast Enhanced MRI

Andrew Melbourne1

1University College London, London, United Kingdom

This work is a review of techniques for retrospective automatic image registration techniques in dynamic contrast enhanced (DCE) MRI. Due to the length of time required to obtain a DCE MRI series image registration techniques are used to correct subject movement between imaging volumes prior to physiological model-fitting to extract features of the enhancement pattern. These techniques are often modified for the DCE setting so that they separate motion artefacts from contrast enhancement. Due to the proliferation of techniques a review is worthwhile so that knowledge of the technical details of image registration can be made more widely available.

Keywords

able accurate alignment application applied apply artificial assessing assumptions attempt authors automatic available better breast briefly calculation carried categories clinical college common comparative components computationally considering constraint contrast correcting cost crucial crucially deform deformation derivatives dissimilarity drawn duration dynamic efforts enhanced enhancement enhancing establishes exemplar extent extraction field fitted fitting focus form framework free fundamental generates generic good heuristic ideally identical illustrative importance improve improved improving intensity interpolation interpretation justify length local locally location longer loosely made many matched matrix measure menagerie model motion movement nature nonrigid open optimal original outcome outline outputs pattern physiological place practice prior procedure process properties quality rapidity reason registered registration registrations reported reproducible required residuals restrict retrospective review rigid sensitivity series setting similarity simulated since smoothness source spec step stimulated strategies strategy subject subsequent subsequently summary suppress take temporal theory thirdly though tissue toward trans transformation uncorrected unlikely validated validity visible volume whether widely worthwhile