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Abstract #4272

Fast Mapping of Absolute Water Content in the Human Brain Using TAPIR

Klaus H. M. Mllenhoff1, 2, Fabian Keil1, Zaheer Abbas1, Vincent Gras1, Miriam Rabea Kubach1, Ana-Maria Oros-Peusquens1, N. Jon Shah1, 3

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Jlich, Jlich, Germany; 2Department of Cognitive Neuroscience, University Maastricht, Maastricht, Netherlands; 3JARA - Faculty of Medicine, RWTH Aachen University, Aachen, Germany

Absolute water content in the human brain is highly regulated and shown to change in various diseases.Thus mapping of H2O values in clinical acceptable measurement times is of great interest. Here we present a fast and accurate method for mapping H2O values in vivo based on the 2D TAPIR approach.

Keywords

absolute accurate acquisition additional additionally adiabatic agreement amongst application array better bias brain calibrate calibrated cerebral channel cognitive coil coils combined content contents correct corrected dataset depicts diseases efficiency employs encephalopathy external faculty fast feasible field finite fitting fluid goal good hardware head healthy hepatic highly histogram human implemented in vivo influenced institute inter inversion investigation known last literature male mapping maps maria measured medical medicine modified parallel passed patent peak probes profiles prone proposed protocol pulse quantitative reach receiver reduce regulated representative reproducibility required resolution respectively routine segmentation sensitive sensitivities shah since slice slices software spinal stroke subject subjects system table tapir things together transmission trio unified variability various version volunteer volunteers water white