Meeting Banner
Abstract #4268

Chemical Exchange Saturation Transfer (CEST) Imaging Using Interleaved Balanced Steady State Free Precession (SSFP)

Zhongliang Zu1, 2, Ke Li1, 2, Richard Dortch1, 2, Seth Smith1, 2, Mark D. Does1, 2, John Gore1, 2, Daniel Gochberg1,<s

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Department of Radiology, Vanderbilt University, Nashville, TN, United States

Conventional CEST sequences contain a long saturation block (several seconds of continuous wave or pulsed irradiation) before acquisition. To fill k-space, several saturation blocks followed by acquisitions may be required, especially in high-resolution imaging. The long scan time limits CEST imaging in clinical applications. Here we present a new CEST imaging method using interleaved balanced steady state free precession (SSFP) acquisitions (named SSFP-CEST) to shorten imaging time. Experiments on creatine/agar phantom show that the SSFP-CEST has similar contrast as that of pulsed-CEST, but the total acquisition time decreases by a factor of ~6.

Keywords

acquisition acquisitions allow alternating applicable application applications applied applying around attenuated attenuation axes balanced block body bridge bright buildup bulk cancer caused chemical clinical coil continuous control conventionally defined detail directly dummy duration efficiency enhance equipped exchange excitation facilitates field forming free frequency fully funding generic geometry gives gore gradient gradients greater greatest head hence highly incorporated indicate initial instead institute interleaved interruption interspersed investigate irradiated irradiation irradiations label labeled least likely likewise limit lipid lipids long longer longitudinally magnetization makes mark measuring minutes modest modification modified named negative offset perhaps periodically phantom plus positive power precession programming proposed protons pulse pulsed pulses radiology rapid reach repeats replaced resolution respectively rewound roughly sample saturating saturation scanner schematic segment selective setting several slice smith solute solutes solution space spatial spectra spectrum spin spoiler steady still stored stroke structures suppress suppressed suppression system systems though transfer transverse typically unit view water wave zero