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Abstract #4266

Development of a 3D CEST Pulse Sequence with Embedded Field Map and Low SAR for PH-Weighted Contrast in Stroke Patients

Chao Xu1, 2, Christian Labadie, 23, Andr Pampel2, Jochen B. Fiebach1, Harald E. Mller2

1Center for Stroke Research Berlin (CSB), Charite-Universitaetsmedizin Berlin, Berlin, Germany; 2Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 3Laboratoire de Spectromtrie Ionique et Molculaire, Universit Claude-Bernard Lyon 1, Villeurbanne, France

Chemical exchange saturation transfer (CEST) permits the detection of dilute labile proteins to allow pH-weighted imaging. However, clinical applications of the technique are currently limited due to time and specific absorption rate (SAR) restrictions. We developed a three-dimensional (3D) pulse sequence with low SAR and embedded field map information. Potential application for detecting ischemic acidosis is demonstrated in a stroke patient imaged on the second day after symptom onset.

Keywords

abnormal absorption according accumulated acidosis acquisition added additionally adjust allow amide amplitudes animal application around asymmetric blood brain buffered central chemical clinical coding cognitive computing conditions consistent contrast corrected correction cortex currently cycle deficit design detail detecting detection developed development dilute dimensional distance duration duty echoes edge embedded ensured examination exchange explained explore fate field flash frequency gradient great hard human implemented included indicated infarct infarction institute integrated intensities interpolated introduced labeled labile lactate leads least limit limited long magnetization male match matches measured measuring might offset onset optimize part partition patient patients peak perfusion permits phantom phosphate potential preliminary previous processing proteins protons pulse pulses rather reach reached readout receives reconstruction recorded reduced reducing repetition repetitions require resonate restrictions reveal risk sampling saturation save scanner scheme separate shortest since solution space spectra spectrum steady stroke studies suggests supply symptom system tissue toward trains transfer transit trio tubes turbo twice water