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Abstract #4258

Optimization of Saturation Pulse Length in Parallel Transmission Based Amide Proton Transfer MRI for Oncology Applications

Jochen Keupp1, Osamu Togao2, Jinyuan Zhou3, Yuriko Suzuki4, Takashi Yoshiura2

1Philips Research, Hamburg, Germany; 2Department of Clinical Radiology, Kyushu University, Fukuoka, Japan; 3Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 4Philips Electronics Japan, Tokyo, Japan

Amide proton transfer (APT) offers a novel route to sensitive MR molecular imaging of endogenous cytosolic proteins and is expected to play an important role in delineation/classification of active tumor tissue for therapy planning/monitoring. The length of RF saturation (Tsat) is a key for sensitivity, in particular at low protein concentrations. With novel parallel transmission based techniques, Tsat>1s is possible on clinical scanners. A thorough protocol optimization is needed for tumor contrast and contrast-to-noise ratio. In a phantom study and acquiring first exemplary clinical brain tumor data, the effect of Tsat on the APT contrast is studied in the range of Tsat=0.5s up to 4s.

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Keywords

active adjusted alternate alternation amide amplifier applications arbitrarily asymmetry back bandwidth behavior better body brain calibration cancer channel channels chicken classification clinical coil complex concentration concentrations consent continues contrast correction cycle decrease depending detect differentiation dimensions displays eddy electronics enable endogenous equal equalized equilibrium example exchange expected fixing frequency furthermore gain good hamburg head homogeneity identical importance important in vivo increasing influence institutional interpolation japan johns lagging length lengths linear long longer macromolecules magnetization maps matrix metastasis minimize minutes mixture model nevertheless novel offsets operation optimal optimization overall parallel particular particularly peptides phantom pixel pronounced proof protein proteins protocol protocols proton pulse pulses quantified radiation radiology rainbow recently reception recurrent reduces reflect reflecting reflects refocusing registered requires review rigid rise role saturation scale scanner scanners schemes school selected sensitive sensitivity serve shimming significantly slowly software specifications spin step strength target therapy tissue transfer transformations transmission tumor types typically underline variation water white whole