Meeting Banner
Abstract #4241

Reproducibility of Myocardial T1 Estimation with Modified CINE-IR in Rat Myocardium at 7T

Henk Smit1, A. Ruggiero1, G.N. Doeswijk1, M. Milanesi2, 3, G.C. Houston4, M.R. Bernsen1, G.P. Krestin1, S. Klein1, G. Kotek1

1Erasmus MC, Rotterdam, Zuid Holland, Netherlands; 2Agilent Technologies UK Ltd.; 3MRI Lab, Fondazione G. Monasterio-CNR, Pisa, Italy; 4GE Healthcare, Netherlands

This work addresses the feasibility, accuracy and the sensitivity of a novel T1 mapping method in rat myocardium at 7.0 T. With the modified Cine Inversion Recovery (mCINE-IR), the effective TR can be adjusted to allow much higher longitudinal recovery between two subsequent inversions pulses than with conventional methods. Furthermore the magnetization recovery is monitored by the CINE loop acquisition for the entire number of RR intervals within the chosen TR. The results show that mCINE-IR offers a reproducible T1 estimation of both healthy tissue and injected Gd labelled cells in the rat myocardium at 7T making longitudinal studies feasible.

Keywords

account accuracy acquisition addresses adjusted align allow anatomical animals anterior array arrow artifacts assessed becomes bound boundary bounds capability cardiac caused cell cells channel chosen cine coil created curve curves days determined deviation discovery distance distribution divided drawn easy effective entire estimation estimator evaluated even experiences extra faces fairly feasibility feasible field fits five furthermore getting gives good healthy heart injected injecting injection inner insufficient intensity interface interpreted interval intervals inversion inversions known labeled landmarks likelihood limitations location longitudinal loop lung magnetization magnitude making many mapping maps minutes modified monitored much mutual myocardial myocardium noise novel offers outer placed played potentially previously problematic procedure produce proper proposed pulse pulses receiver recovery registration reliable reported represent reproducibility reproducible resolution rigid scanned scanner segment segmented segments selected selecting sensitivity severe square stage stem strengths studies subsequent suffer surface surgery susceptibility takes technologies tissue tracking transformation transmitter transplant uncertainty user variation volume whereas yields