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Abstract #4185

Intrinsic Field Homogeneity Correction in Fast Spin Echo Based Amide Proton Transfer MRI

Jochen Keupp1, Holger Eggers1

1Philips Research, Hamburg, Germany

Amide proton transfer (APT), a powerful technique for molecular imaging of endogenous proteins, is based on an asymmetry analysis of RF saturation frequency offsets acquired around the water resonance, which needs precise B0 homogeneity correction. While fast spin-echo (FSE) based APT has superior contrast-to-noise ratio, the previously shown multi-echo APT acquisition with intrinsic Dixon-type B0 mapping/correction is restricted to gradient-echo sequences. We propose a FSE-Dixon APT technique with varied echo time shifts, using iterative Dixon reconstruction across different positive saturation frequency offsets for intrinsic B0 mapping and correction. Feasibility in the human head is demonstrated using a clinical 3T scanner.

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Keywords

acquisition actual almost alternatively amide amplifier amplitude around asymmetry available avoided bandwidth bias biased body brain cause chem clinical coil concentrations consistent constant control corrected correction dataset detection deviation driven efficiency efficient enable endogenous enhance envisioned equilibrium equivalent estimation evaluation examination exchange extra fast feasibility field frequency full furthermore gradient hand head healthy hence homogeneity homogeneous human in vivo inaccuracy inhomogeneity integrated interpolated intrinsic iterative local long maintaining mapping maps matrix minutes mixed mode moderate molecular must negative negligible neurology nevertheless noise novel offset offsets partly percent pixel positive possibility power precise precisely precision preferable presence previously promising prone propose protein proteins proton protons pulse pulses quadrature quality radiology readout receive reconstruction reeder reflects refocusing resolution resonant robust sampling saturation scanner scanning selecting separation series shot simplified since software spatially spin steps still stroke strong successfully symmetric transfer translated transmit tumor tumors type typical typically uncorrected uniformly variants variations varied varies volunteer water