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Abstract #4172

Volumetric Fat Quantification of Intra-Abdominal Adipose Tissue from a Single Breath Hold Acquisition

Bryan T. Addeman1, Abraam S. Soliman2, 3, Curtis N. Wiens4, Charles A. McKenzie1, 4

1Department of Medical Biophysics, University of Western Ontario, London, ON, Canada; 2The Robarts Research Institute, London, ON, Canada; 3Biomedical Engineering, University of Western Ontario, London, ON, Canada; 4Department of Physics and Astronomy, University of Western Ontario, London, ON, Canada

Escalating interest in the studies of obesity and metabolic disease has created a demand for techniques to measure the regional distribution of adipose tissue. Current standards employ manual segmentation of fat on a single slice, and extrapolation to estimate total fat volumes. We propose a novel automated tissue segmentation technique on images acquired from the entire intra-abdominal cavity within a single breath-hold. Volunteers were imaged in less than 10 minutes, and the images were analyzed in under 2 minutes. Results are similar to those obtained by manual segmentation, but require no manual intervention and are calculated very rapidly.

Keywords

abdominal ability accelerated accurately acknowledge acknowledgments acquisition addition additional adipose adjusted affected agrees approval array astronomy automated bias biomedical biophysics bland breath calf cardiovascular caused cavity chairs channel clinical coil collect collected comfortable completed confidence cover dashed datasets development diaphragm diminished discarded distal echoes ends engineering entire equally extending extra floor fraction gratefully great healthy hold hours house ideal importance in vivo include included increasing individual inferior inside institute intensities intensity internal interval intervention intra layer least length locate located long manual manually maps matrix measured medical minutes nature needed none novel obesity padded parallel partial patient pattern pelvic physics pixels plot positive predicted problem propose pulse quality quantification quantify rapid rapidly recognized regional removed reproducibility require required sampling scanned scanner segment segmentation sensitivities sensitivity since slice slices solid subcutaneous successful sufficient superior support table term thigh thresholds tissue torso toward transverse uniform variations view volume volumes volumetric volunteer volunteers water western zero