Meeting Banner
Abstract #4112

The Influence of Model Used to Fit DW-MRI Data on Apparent Diffusion Coefficient Estimates and Their Reproducibility in Normal Tissues

Nina Tunariu1, David J. Collins1, Matthew Orton1, James A. d'Arcy1, Veronica A. Morgan1, Sharon L. Giles1, Nandita M. deSouza1

1CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden Hospital, Sutton, London, United Kingdom

Diffusion Weighted MRI is considered a potential biomarker for anticancer therapy response. The literature suggests that assumption of a simple exponential relationship between signal attenuation and b value for ADC calculation may be too simplistic and that using more complicated mathematical models which account for the non-monoexponential behaviour of the diffusion signal attenuation in tissues results in a better data fitting and potentially less variable ADC estimates. The purpose of this study was to evaluate the influence of the mathematical model used to fit the DW-MRI data on the ADC values and their reproducibility.

Keywords

able account accounts acknowledge adept affected affects apart apparent approaches assessed assessment association assumption attenuation available averaging axis best better bland breathing calculation cancer care chain choice clinical closely coefficient combination complex complicated continuous corrected cortex criteria days decay decaying dependent described describes deviates diffusion distribution drew early england envisage experienced explore exponential extent fitted fitting free funding goodness grant health healthy heterogeneity highest hospital house improved include incoherent increasing increasingly indicate influence initial institute intensity interpolated invest kidney kidneys kingdom kurtosis larger linear literature liver lobe lowest matched mathematical matrix median model models motion muscle needed negative organ organs orthogonal part perfusion pixels planar potential potentially preferred quantified radiologist radiology refer regression related relationship renal represents reproducibility require residuals response scanned shot simple simplistic smallest solver solvers spleen stretched studies subject subjects suggests support system table takes therapy throughout tissues trials twice variable variation veronica vessels visits visually volunteer water