Meeting Banner
Abstract #4099

Obesity-Related Variations in T2* and Fat Content of Murine Brown and White Adipose Tissues by Chemical-Shift MRI

Houchun Harry Hu1, 2, Catherine D. G. Hines3, Scott B. Reeder4

1Radiology, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA, United States; 2Electrical Engineering, University of Southern California, Los Angeles, CA, United States; 3Merck Research Laboratories, West Point, PA, United States; 4Radiology, Medical Physics, Biomedical Engineering, and Medicine, University of Wisconsin-Madison, Madison, WI, United States

We utilized a chemical-shift water-fat MRI technique to characterize T2* and proton density fat-fraction (PDFF) differences between interscapular brown (BAT) and gonadal white (WAT) adipose tissues in lean and genetically obese mice. Lean mice (n=6) and two groups of obese ob/ob mice placed on four-week (n=6) and eight-week (n=8) diets were studied. Comparing within each group, BAT T2* and PDFFs were consistently lower than WAT (p<0.001). Comparing across groups, longer BAT T2* and greater BAT PDFFs were measured in older and more obese ob/ob mice than lean mice (p<0.001). Collectively, these observations reflect the lean groups greater BAT thermogenic activity.

Abstract PDF E-Poster Video

Keywords

absence absent accounts activation activity adipose ambient anesthetics animal animals appear bandwidth bias biomedical blood body brown characterized chemical children chow closer coil comparing complex confounding consisting content contrast control core counterpart decomposition demand densely depot detectable detection diets distributions dorsal drawn easily eddy eight either energy engineering evident example examples excess exploited feasibility flow form foster functions furthermore generate gonadal greater hagen harry heat horizontally hospital hypothesize ideal illustrates impaired imperfections in vivo inhomogeneity insulation intake invasive investigate iron lead lean length maintain maps measured measures metabolic metabolically metabolizes metrics mice mouse near nominal note obese obesity outlines particularly peak perimeter physics placed prepared presence produced properties proton pulse quantitative radiology recent record reduced reeder remain respectively respiratory rodent scale scanned sedated shape significantly since slice smaller southern spacing spectroscopy spectrum stimulated summarize supply surrounding system table temperature tissue tissues train triangle triangular utilized variations visible water weeks west white wild words