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Abstract #4082

Effects of in vivo Flip Angle Variations on the Accuracy of DCE-MRI Perfusion Parameters at 1.5T and 3.0T

Jiangsheng Yu1, Xia Zhao1, Yiqun Xue1, Mark A. Rosen1, Christina S. Chu2, Hee Kwon Song1

1Departments of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, United States

The goal of this work is to determine to what extent flip angle deviations affect DCE-MRI perfusion parameter accuracy on three different MRI systems, including whether higher fields and short bore systems can potentially exacerbate these measurement inaccuracies. The results show that over a large region of the body, the ranges of flip angle deviations are similar for the three systems. These variations can potentially mask true changes in tumor treatment response, and flip angle mapping may be a crucial in DCE-MRI protocols.

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Keywords

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