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Abstract #4073

Intra-Renal Oxygenation in Contrast Induced Nephropathy Model by BOLD MRI: Comparison of Four Radio-Contrast Agents

Lu-Ping Li1, Hongyan Du2, Tammy Franklin3, Ujala Bokhary3, Maria Papadopoulou-Rosenzweig4, Richard Solomon5, Pottumarthi V. Prasad3

1Radiology Dept., Northshore University Healthsystem, Evanston, IL , United States; 2Center for Clinical & Research Informatics, Northshore University Healthsystem, Evanston, IL, United States; 3Radiology Dept., Northshore University Healthsystem, Evanston, IL, United States; 4Radiation Oncology, Northshore University Healthsystem, Evanston, IL, United States; 5Medicine, Fletcher Allen Health Care, Burlington, VT, United States

Radio-contrast induced nephropathy (CIN) is the 3rd common cause of in-hospital mortality in patients with pre-existing kidney insufficiency. Physico-chemical properties of the contrast media are known to influence their risk profile. Renal hypoxia is known to play a role in the pathophysiology of CIN and BOLD MRI has been shown to be useful in monitoring the changes in intra-renal oxygenation following administration several pharmacological agents including radio-contrast media. Here, we report for the first time, a direct comparison among four radio-contrast agents with different physic-chemical properties (monomer/dimer, iconicity, osmolality, viscosity) using BOLD MRI.

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